Angiotensin Converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system (RAS), involved in regulating blood pressure and fluid balance by converting angiotensin I to the potent vasoconstrictor angiotensin II. 

Higher than normal ACE level may be a sign of sarcoidosis. ACE levels may rise or fall as sarcoidosis worsens or improves. A higher than normal ACE level may also be seen in several other diseases and disorders, including: Adrenal glands do not make enough hormones (Addison disease)

ACE is present in different cell types, but its principal location is on the surface of endothelial and epithelial cells [56]. In humans, ACE is encountered in two distinct isoforms, the somatic and the germinal isoform.