C-ANCA (Serine Proteinase 3)

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The C-ANCA test detects antibodies against Proteinase-3, used to diagnose and monitor ANCA-associated vasculitis.

₹799.00 ~~₹2000.00~~

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Test Details

Also Known As

PR3-ANCA Test, C-ANCA PR3 Antibody Test, Anti-Proteinase 3 Antibodies, Cytoplasmic ANCA Test, ANCA Vasculitis Test

Sample Type

Blood

Gender

Male, Female

Age Group

Adolescents and Adults

Pathology

Test Code

C-ANCA (Cytoplasmic Anti-Neutrophil Cytoplasmic Antibodies) directed against Serine Proteinase-3 (PR3) are autoantibodies commonly associated with ANCA-associated vasculitis, especially granulomatosis with polyangiitis (GPA). This blood test helps in diagnosing systemic small-vessel vasculitis, assessing disease activity, and monitoring response to immunosuppressive therapy. Elevated PR3-ANCA levels correlate with active disease in many patients, though results must be interpreted alongside clinical findings, imaging, and histopathology, as low levels may occasionally be seen in other inflammatory or autoimmune conditions.

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Frequently Asked Questions

It suggests ANCA-associated vasculitis, especially granulomatosis with polyangiitis.

No, C-ANCA targets proteinase-3, while P-ANCA commonly targets myeloperoxidase (MPO).

Yes, levels may decrease with effective treatment, though clinical correlation is essential.

No fasting is required.

Occasionally, low levels may be seen in other autoimmune or inflammatory disorders.

A blood sample is analyzed using immunoassay techniques such as ELISA.

C-ANCA (Serine Proteinase 3)