C-ANCA (Serine Proteinase 3)

PR3-ANCA is a highly specific biomarker for granulomatosis with polyangiitis and is a highly specific biomarker for eosinophilic granulomatosis with polyangiitis or microscopic polyangiitis.

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ANCA-PR3-positivity is predominantly found in patients with Wegener's granulomatosis and microscopic polyangiitis. ANCA-MPO-positivity is also found in patients with microscopic polyangiitis as well as in patients with other vasculitides and auto-immune conditions.

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Serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. PR3-ANCA is a useful serological marker for disease severity in ulcerative colitis (UC).